Associations between continuous glucose monitoring (CGM) metrics and psycholinguistic measures: a correlational study.

AIM: Recently, the relationship between diabetes and mental health has been widely studied. With the advent of continuous glucose monitoring (CGM), some researchers have been interested in exploring the association between glucose-related metrics and psychological aspects. These studies have primarily relied on self-report questionnaires which present some limitations. Therefore, the present multicenter study aims at testing potential associations between CGM metrics and affective processes derived from narratives about using a CGM sensor. METHODS: An exploratory correlational design was used. Fifty-eight adults with type 1 diabetes using CGM were enrolled and invited to complete an online survey, where they replied to an open-ended question regarding their personal experience with the CGM sensor. Texts derived from the answers were analyzed through Linguistic Inquiry and Word Count, a widely used text analysis tool that can automatically identify and quantify linguistic patterns related to various psychological dimensions. Psycholinguistic measures were correlated with CGM metrics. RESULTS: Higher levels of sadness/depression correlated with lower %TIR (r = - 339; p < .01) and higher %TAR (r = .342; p < .01). CONCLUSIONS: The study highlights the relationship between CGM metrics and psychological variables derived from patients' narratives. In particular, it is possible to hypothesize a positive role of %TIR in reducing depressive feelings in individuals with diabetes, as well as a negative role of depressive feelings in achieving desirable CGM outcomes. Additionally, there is a potential role of glycemic variability, particularly hyperglycemia, in the expression of depressive and sad feelings, which has been less studied compared to the effects of hypoglycemia.

Indirect orthodontic bonding using an original 3D method compared with conventional technique: A narrative review.

As well known success in orthodontics is related to a correct diagnosis and to a carefull treatment planning. Our study aims to provide clinician with a reproducible and precise method, for orthodontic indirect bonding, thanks to CBCT images and due to a CAD-CAM process. METHODS: A case of an orthodontic treatment plan, of a female patient, 37 years old, was selected. Plaster models were digitally acquired using the Extra-Oral scanner Maestro 3D and processed within the Studio Maestro 3D software. CBCT images in DICOM format were imported into the MIMICS software, in order to perform the segmentation of the dental elements, and to obtain a three-dimensional coronal-root dental arches model. The DICOM file thus processed was exported in an STL file, reworked with Meshmixer software to improve image quality, and imported into the 3D Maestro software to be superimposed on the digital model. In this way a three-dimensional real model of the dental arches was developed. After an accurate orthodontic virtual set-up, we proceeded to brackets positioning on the 3D model of the dental arches. Subsequently, a virtual transfer template was created, in order to carry out the digital printing of a thermo-printed mask necessary to perform an indirect bonding of the orthodontic appliance. RESULTS: The original digital workflow proposed in this study allows the development of a real and non-ideal three-dimensional coronal-root model of the dental arches; this model can be used for indirect orthodontic bonding eliminating any errors in the expression of 1st, 2nd and 3rd order information of the pre-informed orthodontic appliance. CONCLUSIONS: Technological advancements in oral scanning and 3D printing will allow the achievement of an easy and reproducible ideal positioning of the orthodontic brackets.

Leaders' Role in Shaping Followers' Well-Being: Crossover in a Sample of Nurses.

The link between well-being at work and leadership has received considerable attention. Leaders have the power to influence followers not only due to formal position, but also their positive behaviors could reinforce the followers' positive working experience. Following the crossover model (Westman, 2001), this study investigates whether leaders' work-related positive psychological states (i.e., work engagement) cross over to those of the followers (i.e., work engagement and job satisfaction) through the mediation of the latter's perception of transformational leadership. We used MPlus 8 to test two multilevel mediations in a sample of 1505 nurses nested in 143 groups led by as many leaders (87.19% of nurses and 56.50% of head nurses of the entire population). Results show that while there is not a crossover of leader work engagement to nurse work engagement, manager work engagement can cross over to nurse job satisfaction, enhancing their well-being through transformational leadership behaviors. This study adds further insights both on crossover theory and on the importance of leaders in expanding and transferring resources to followers at work. Fostering work engagement at a managerial level in the healthcare sector could be the driver to facilitate the well-being of nurses at work, address negative outcomes, and promote positive ones.

Comparison of Low-Redshift Lyman-α Forest Observations to Hydrodynamical Simulations with Dark Photon Dark Matter.

Recent work has suggested that an additional ≲6.9 eV per baryon of heating in the intergalactic medium is needed to reconcile hydrodynamical simulations with Lyman-α forest absorption line widths at redshift z≃0.1. Resonant conversion of dark photon dark matter into low frequency photons is a viable source of such heating. We perform the first hydrodynamical simulations including dark photon heating and show that dark photons with mass m_{A^{'}}∼8×10^{-14} eV c^{-2} and kinetic mixing ε∼5×10^{-15} can alleviate the heating excess. A prediction of this model is a nonstandard thermal history for underdense gas at z≳3.

The use of concept maps as an assessment tool in students' risk education about occupational safety and health.

Given the relevance of students' risk education about occupational safety and health (OSH), the need for reliable assessment tools for learning evaluation is widely advocated. However, multiple-choice tests or inventories show several limitations, including the emphasis on basic definitions instead of organized conceptual systems and passive information transfer. Instead, concept maps may represent a non-traditional evaluation tool to inspect how students actively organize and represent the acquired knowledge in line with the theory of meaningful learning. A concept map specifically developed in the field of risk education and its quantitative scoring protocol are here proposed. Then, a case study with a pre- post-test design is presented, including 611 upper school students who undertook an OSH-related risk educational course. The findings are briefly discussed and help identify the possible information we can get from concept maps in terms of problem-based learning.

Legume NCRs and nodule-specific defensins of actinorhizal plants-Do they share a common origin?

The actinorhizal plant Datisca glomerata (Datiscaceae, Cucurbitales) establishes a root nodule symbiosis with actinobacteria from the earliest branching symbiotic Frankia clade. A subfamily of a gene family encoding nodule-specific defensin-like cysteine-rich peptides is highly expressed in D. glomerata nodules. Phylogenetic analysis of the defensin domain showed that these defensin-like peptides share a common evolutionary origin with nodule-specific defensins from actinorhizal Fagales and with nodule-specific cysteine-rich peptides (NCRs) from legumes. In this study, the family member with the highest expression levels, DgDef1, was characterized. Promoter-GUS studies on transgenic hairy roots showed expression in the early stage of differentiation of infected cells, and transient expression in the nodule apex. DgDef1 contains an N-terminal signal peptide and a C-terminal acidic domain which are likely involved in subcellular targeting and do not affect peptide activity. In vitro studies with E. coli and Sinorhizobium meliloti 1021 showed that the defensin domain of DgDef1 has a cytotoxic effect, leading to membrane disruption with 50% lethality for S. meliloti 1021 at 20.8 µM. Analysis of the S. meliloti 1021 transcriptome showed that, at sublethal concentrations, DgDef1 induced the expression of terminal quinol oxidases, which are associated with the oxidative stress response and are also expressed during symbiosis. Overall, the changes induced by DgDef1 are reminiscent of those of some legume NCRs, suggesting that nodule-specific defensin-like peptides were part of the original root nodule toolkit and were subsequently lost in most symbiotic legumes, while being maintained in the actinorhizal lineages.

Low-Energy Supernovae Severely Constrain Radiative Particle Decays.

The hot and dense core formed in the collapse of a massive star is a powerful source of hypothetical feebly interacting particles such as sterile neutrinos, dark photons, axionlike particles (ALPs), and others. Radiative decays such as a→2γ deposit this energy in the surrounding material if the mean free path is less than the radius of the progenitor star. For the first time, we use a supernova (SN) population with particularly low explosion energies as the most sensitive calorimeters to constrain this possibility. These SNe are observationally identified as low-luminosity events with low ejecta velocities and low masses of ejected ^{56}Ni. Their low energies limit the energy deposition from particle decays to less than about 0.1 B, where 1 B(bethe)=10^{51} erg. For 1-500 MeV-mass ALPs, this generic argument excludes ALP-photon couplings G_{aγγ} in the 10^{-10}-10^{-8} GeV^{-1} range.

The Perception of Water Contamination and Risky Consumption in El Salvador from a Community Clinical Psychology Perspective.

This study was carried out as part of the international cooperation project "Agua Futura" for the improvement of water resource management and the promotion of water, sanitation, and hygiene (WASH) behaviors in rural communities of Central America. Given the relevant healthcare problem of water pollution, especially in El Salvador, the aim was to detect some key factors affecting the perception of water contamination and its risky consumption from a community clinical psychological perspective. Ninety rural inhabitants of El Salvador were administered a structured interview exploring their perceptions about water quality and the impact of water consumption on health. Data were analyzed through a computer-aided thematic analysis-complemented by a qualitative analysis-allowing the detection of sense-making processes based on lexical variability. Different themes were identified with regard to the perception of water quality (i.e., mistrust, danger, and safety) and the beliefs about the impact of water consumption on health (i.e., rationalization, denial, awareness, displacement, and isolation of affect). The results showed heterogeneous perspectives about water quality and sanitation. However, the perceived negative impact of water consumption on health was mostly denied or minimized through massive distortions. Overall, the study highlights the role of defensive patterns in facing issues of water contamination, which may prevent the community from adopting healthy behaviors and adequate water management behaviors.

Understanding care relationships in diabetes practice: A psychodynamic interview-based exploratory study.

OBJECTIVE: To explore the subjective experience of physicians working in diabetic settings about their care relationships in order to find some unique clues contributing to physician professional health and capacity to manage patients' adherence. RESEARCH DESIGN AND METHODS: An interview-based exploratory study has been carried out involving 18 physicians (77.8% female) with at least 3 years of clinical practice in diabetes care. In-depth interviews about the emotional experience with patients with diabetes were conducted and audio recorded. Interviews transcripts were analyzed through a computer-based text analysis which allowed the identification of thematic domains (Cluster Analysis) and latent factors (Correspondence Analysis) viewed through a psychodynamic and constructivist lens. RESULTS: Six thematic domains emerged respectively referring to: Concern (8.43%), Control (14.42%), Ambivalence (22.08%), Devotion (22.49%), Guilt (19.29%) and Strive for Achievement (13.30%). Moreover, three latent dimensions were taken into account, which explained 69.20% of data variance: Affect Repression (28.50%), Tendency to Repair (22.70%) and Anxiety Pattern (18.00%). CONCLUSIONS: Overall, the results of the present study confirm the challenging nature of diabetes care. In particular, physicians ongoing effort to restore patients' psychological integrity in chronic condition constitute the most novel finding above all. In this regard, the need for emotional labor in physicians' education and training is suggested in order to both prevent burnout symptoms (e.g. depersonalization) and promote shared decision making in care relationships. However, findings should be treated as preliminary given the convenience nature of the sample and its reduced size.

The need to restore generative identity in women undergoing assisted reproductive technology: Development and psychometric validation of the fertility reparation inventory.

OBJECTIVE: This study described the development and psychometric evaluation of the fertility reparation inventory, providing measures of manic and expiatory reparation as symbolic dynamics of restoring one's procreative and generative identity through Assisted Reproductive Technology (ART). METHODS: Two cross-sectional studies were conducted on female patients undergoing ART (N = 150) and women from the general population (N = 250), respectively. Exploratory factor analysis and confirmatory factor analysis assessed construct validity and reliability. Pearson's bivariate correlations were used to provide convergent evidence of validity with omnipotence, perceived infertility-related stress, anxiety, depression, need for reparation, fear of punishment, and hope. RESULTS: The results confirmed a two-factor solution of the 12-item instrument, with adequate fit, a very good internal consistency, and well-supported forms of convergent validity. CONCLUSION: This study provides a meaningful psychodynamic contribution, in both theoretical and empirical terms, for the understanding of emotional dynamics and psychological issues underlying the demand for ART.

Repetita Iuvant? A Repeated Randomized Controlled Trial on the Effectiveness of an At-Scale Teacher Professional Development Program.

A recent stream of literature recognizes the impact of good/poor implementation on the effectiveness of programs. However, implementation is often disregarded in randomized controlled trials (RCTs) because they are run on a small scale. Replicated RCTs, although rare, provide a unique opportunity to study the relevance of implementation for program effectiveness. Evaluating the effectiveness of an at-scale professional development program for lower secondary school math teachers through two repeated RCTs. The program lasts a full school year and provides innovative methods for teaching math. The evaluation was conducted on two cohorts of teachers in the 2009/10 and 2010/11 school years. The program and RCTs were held at scale. Participating teachers and their classes were followed for 3 years. Impact is estimated by comparing the math scores of treatment and control students. The evaluation involved 195 teachers and their 3940 students (first cohort) and 146 teachers and their 2858 students (second cohort). The key outcome is students' math achievement, measured through standardized assessment. In the first wave, the program did not impact on students' achievement, while in the second wave, a positive, persistent, and not insignificant effect was found. After excluding other sources of change, different findings across waves are interpreted in the light of improvements in the program implementation, such as enrollment procedure, teacher collaboration, and integration of innovation in daily teaching. Repeated assessment of interventions already at-scale provides the opportunity to better identify and correct sources of weak implementation, potentially improving effectiveness.

"Don't Stop the Music," Please: The Relationship between Music Use at Work, Satisfaction, and Performance.

Although there are several studies in the literature that have examined how different types of music affect performance or other organisational outcomes, knowledge about how music affects individuals in the workplace is still limited, especially in terms of perceived music use. This study aims to examine the effects of three different uses of music-namely, emotional, cognitive, and background music-on individual perceptions of job satisfaction and performance. A sample of 244 workers from different backgrounds was included in the study. We tested a full structural equation model. The results show that (1) emotional use has a positive relationship to performance, both directly and indirectly through mediating job satisfaction; (2) cognitive use has no significant effect on satisfaction and performance (even indirectly); and (3) background use has a negative relationship to job satisfaction and no relationship to performance. This work suggests that listening to music during work activities could be a positive organisational practice. Future studies could further investigate the role of music listening as a resource, taking into account other personal and contextual characteristics.

Axionlike Particles from Hypernovae.

It was recently pointed out that very energetic subclasses of supernovae (SNe), like hypernovae and superluminous SNe, might host ultrastrong magnetic fields in their core. Such fields may catalyze the production of feebly interacting particles, changing the predicted emission rates. Here we consider the case of axionlike particles (ALPs) and show that the predicted large scale magnetic fields in the core contribute significantly to the ALP production, via a coherent conversion of thermal photons. Using recent state-of-the-art supernova (SN) simulations, including magnetohydrodynamics, we find that, if ALPs have masses m_{a}∼O(10) MeV, their emissivity in such rare but exciting conditions via magnetic conversions would be over 2 orders of magnitude larger than previously estimated. Moreover, the radiative decay of these massive ALPs would lead to a peculiar delay in the arrival times of the daughter photons. Therefore, high-statistics gamma-ray satellites can potentially discover MeV ALPs in an unprobed region of the parameter space and shed light on the magnetohydrodynamical nature of the SN explosion.

Searching for the Radiative Decay of the Cosmic Neutrino Background with Line-Intensity Mapping.

We study the possibility to use line-intensity mapping (LIM) to seek photons from the radiative decay of neutrinos in the cosmic neutrino background. The Standard Model prediction for the rate for these decays is extremely small, but it can be enhanced if new physics increases the neutrino electromagnetic moments. The decay photons will appear as an interloper of astrophysical spectral lines. We propose that the neutrino-decay line can be identified with anisotropies in LIM clustering and also with the voxel intensity distribution. Ongoing and future LIM experiments will have-depending on the neutrino hierarchy, transition, and experiment considered-a sensitivity to an effective electromagnetic transition moment ∼10^{-12}-10^{-8}(m_{i}c^{2}/0.1 eV)^{3/2}µ_{B}, where m_{i} is the mass of the decaying neutrino and µ_{B} is the Bohr magneton. This will be significantly more sensitive than cosmic microwave background spectral distortions, and it will be competitive with stellar cooling studies. As a by-product, we also report an analytic form of the one-point probability distribution function for neutrino-density fluctuations, obtained from the quijote simulations using symbolic regression.

Job demands and perceived distance in leader-follower relationships: A study on emotional exhaustion among nurses.

BACKGROUND: Emotional exhaustion is the most important component of burnout syndrome, which is a threat to nurses' psychological well-being. OBJECTIVES: The study investigated the impact of job demands - workload, cognitive demands, emotional demands, role conflict - and perceived leader-follower interaction frequency on emotional exhaustion among nurses. METHODS: This study was conducted at three hospitals in northern Italy through an anonymous self-report questionnaire administered to 560 nurses. Multiple hierarchical regression was performed. RESULTS: Workload and role conflict were positively related to emotional exhaustion, whereas cognitive demands and perceived leader-follower interaction frequency were negatively related. Emotional demands displayed a non-significant relationship with emotional exhaustion. Further analyses were performed to comment on the unexpected outcome of cognitive demands. A critical role of the perception of "distance" in leader-follower relationships on burnout was found. CONCLUSIONS: This study provides novel insights into the relationship between job demands and burnout, and much needed empirical evidence on leader-follower relationships among nurses, pointing to the important role played by leader distance in nurses' well-being at work. Findings highlight the importance of training head nurses in managing their working relationship distance from their followers in order to help them soothing emotional exhaustion.

Anxiety Levels Predict Bone Mineral Density in Postmenopausal Women Undergoing Oral Bisphosphonates: A Two-Year Follow-Up.

Clinical psychological factors may predict medical diseases. Anxiety level has been associated with osteoporosis, but its role on bone mineral density (BMD) change is still unknown. This study aimed to investigate the association between anxiety levels and both adherence and treatment response to oral bisphosphonates (BPs) in postmenopausal osteoporosis. BMD and anxiety levels were evaluated trough dual-energy X-ray absorptiometry and the Hamilton Anxiety Rating Scale (HAM-A), respectively. Participants received weekly medication with alendronate or risedronate and were grouped according to the HAM-A scores into tertiles (HAM-A 3 > HAM-A 2 > HAM-A 1). After 24 months, BMD changes were different among the HAM-A tertiles. The median lumbar BMD change was significantly greater in both the HAM-A 2 and HAM-A 3 in comparison with the HAM-A 1. The same trend was observed for femoral BMD change. Adherence to BPs was >75% in 68% of patients in the HAM-A 1, 79% of patients in the HAM-A 2, and 89% of patients in the HAM-A 3 (p = 0.0014). After correcting for age, body mass index, depressive symptoms, and the 10-yr. probability of osteoporotic fractures, anxiety levels independently predicted lumbar BMD change (ß = 0.3417, SE 0.145, p = 0.02). In conclusion, women with higher anxiety levels reported greater BMD improvement, highlighting that anxiety was associated with adherence and response to osteoporosis medical treatment, although further research on this topic is needed.

Addiction Nursing Competencies: A Comprehensive Toolkit for the Addictions Nurse.

With the increased role of nurses in caring for patients with substance addiction, there was a clear need to develop the Addiction Nursing Competencies to guide and support the nursing workforce. A literature search revealed a lack of formal instruments to assess and guide nurses in caring for persons with substance use disorders. The Addiction Nursing Competencies were created using existing nursing education frameworks and addiction nurse care manager clinical guidelines.

Edges and Endpoints in 21-cm Observations from Resonant Photon Production.

We introduce a novel class of signatures-spectral edges and end points-in 21-cm measurements resulting from interactions between the standard and dark sectors. Within the context of a kinetically mixed dark photon, we demonstrate how resonant dark photon-to-photon conversions can imprint distinctive spectral features in the observed 21-cm brightness temperature, with implications for current, upcoming, and proposed experiments targeting the cosmic dawn and the dark ages. These signatures open up a qualitatively new way to look for physics beyond the Standard Model using 21-cm observations.

Alexithymia, Emotional Distress, and Perceived Quality of Life in Patients With Hashimoto's Thyroiditis.

Emotion-processing impairment represents a risk factor for the development of somatic illness, affecting negatively both health-related quality of life (HRQoL) and disease management in several chronic diseases. The present pilot study aims at (i) investigating the associations between alexithymia and depression, anxiety, and HRQoL in patients with Hashimoto's thyroiditis (HT); (ii) examining the association between these three psychological conditions together with HRQoL, and thyroid autoantibodies status as well as thyroid echotexture in patients with HT; and (iii) comparing the intensity of all these clinical psychological features in patients with HT versus controls. Twenty-one patients with serologically or ultrasonographically verified HT and 16 controls with non-toxic goiter or postsurgical hypothyroidism were recruited for this study. Serum thyrotropin (TSH) and free thyroxine, as well as thyroid autoantibodies (thyroglobulin antibodies and thyroid peroxidase antibodies), were assayed. Alexithymia, depression, anxiety, and HRQoL were assessed with Toronto Alexithymia Scale; Beck Depression Inventory, second edition; Hamilton Anxiety Rating Scale; and Health Survey Short-Form 36, respectively. A negative relationship between the difficulty to describe feelings and the cognitive component of depression was found (r = -0.46, p = 0.04). Besides, patients with seronegative HT had lower somatic anxiety than patients with HT who tested positive (r = -0.68, p = 0.01 and r = -0.59, p = 0.04, respectively). Besides, no statistically significant difference was found between patients with HT and controls with regard to somatic anxiety. The present study suggests the relevance of alexithymia in patients suffering from HT, which may be intertwined with a possible state of underreported depression that is mainly expressed through physical complaints. Promoting the capability to describe and communicate feelings could contribute to psychological elaboration and coping with the disease and, consequently, to the improvement of self-management and perceived HRQoL.